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KMID : 0363219960340050784
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Korean Journal of Dermatology
1996 Volume.34 No. 5 p.784 ~ p.789
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The Pattern of Epidermal immune Deposits in patients with High-Titer Anti-Ro Positive Lupus Erythematosus
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Abstract
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Background :
@EN Antibodies to Ro antigen are present in most patients with subacute cutaneous luus erythematosus and in about 50% of Korean patients with systemic lupus erythematosis (LE). However, thepattern of in vivo epidermal deposits of anti-Ro
antibodies
has
not been widely recognized.
@ES Objective :
@EN The purpose of this study was to define characteristic findings of direct and indirect immunofluorescence (IF) in patients with high-titer anti-Ro or anti-Ro/La positive LE.
@ES Methods :
@EN Lupus band test (direct IF with normal appearing forearm skin specimens) and indirect IF with normal skin substrates were performed with 3 patients of systemic LE who have high titers (>1 : 640) of anti-Ro or anti-Ro/La antibodies but have no
antibodies against other nuclear antigens such as Ndna/Sm/nRNP/Scl-70.
@ES Results :
@EN An identical pattern of immune deposits was observed in the epidermis in all 3 patients through direct and indirect IF examinations. The characteristic pattern recognized was "fine speckling" of IgG(or IgG/IgM) mainly at the nuclei on the
basal
keratinocytes or keratinocytes throught the epidermis. In the immunoblot assay performed with one patient, IgG anti-Ro/La antibodies were identified to recognize the 52/42kD antigens (probably, the Ro/La antigens0 in the cultured-keratinocyte
extracts.
@ES Conclusion :
@EN Most direct IF studies in patients with systemic LE(lupus band test) have shown granular depositions of immunoglobulins and complement components along the dermoepidermal junction, however, the staining patterns as observed in this study may
have
been overlooked. The recognizable fine speckled pattern of immune deposits at the epidermal keratinocytes could be taken into account as a positive finding in the broad category of "lupus band", seen with the normal appearing skin in patients
with
systemic LE. Especially, who have high titers of anti-Ro/La antibodies. (Kor J Dermatol 1996;34(5) : 784~789)
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KEYWORD
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